Tranilast inhibits glucose-induced insulin secretion from pancreatic beta-cells.

  title={Tranilast inhibits glucose-induced insulin secretion from pancreatic beta-cells.},
  author={S. Taguchi and N. Ozaki and H. Umeda and N. Mizutani and T. Yamada and Y. Oiso},
  journal={Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme},
  volume={40 8},
  • S. Taguchi, N. Ozaki, +3 authors Y. Oiso
  • Published 2008
  • Chemistry, Medicine
  • Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme
Tranilast, N-(3,4-demethoxycinnamoyl)-anthranilic acid, is an anti-allergic agent identified as an inhibitor of mast cell degranulation. Recently, tranilast was shown to decrease albuminuria in a rat model of diabetic nephropathy and to ameliorate vascular hypertrophy in diabetic rats, suggesting that it may be clinically useful in the treatment of diabetic complications. However, the effects of tranilast on glucose tolerance have not been elucidated. Thus, the aim of this study is to… Expand
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