Tranexamic acid in bleeding trauma patients: an exploration of benefits and harms

@inproceedings{Roberts2017TranexamicAI,
  title={Tranexamic acid in bleeding trauma patients: an exploration of benefits and harms},
  author={Ian Roberts and Phil Edwards and David E. Prieto and Miland Joshi and Abda Mahmood and Katharine Ker and Haleema Shakur},
  booktitle={Trials},
  year={2017}
}
BACKGROUND The CRASH-2 trial showed that tranexamic acid (TXA) administration reduces mortality in bleeding trauma patients. However, the effect appeared to depend on how soon after injury TXA treatment was started. Treatment within 3 h reduced bleeding deaths whereas treatment after 3 h increased the risk. We examine how patient characteristics vary by time to treatment and explore whether any such variations explain the time-dependent treatment effect. METHODS Exploratory analysis were… CONTINUE READING
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