Tranexamic acid for trauma – Authors' reply

  title={Tranexamic acid for trauma – Authors' reply},
  author={Haleema Shakur and Ian Roberts and Pablo Perel},
  journal={The Lancet},

Tranexamic acid and reduction of blood transfusion in lower limb trauma surgery: a randomized controlled study

TXA helps reduce the morbidity of trauma patients by reducing the requirement for blood transfusion and its use is safe in lower limb trauma surgery and lowers the cost of therapy to the patient.

Transfusion strategies in bleeding critically ill adults: a clinical practice guideline from the European Society of Intensive Care Medicine

This clinical practice guideline provides evidence-based recommendations for the management of massively and non-massively bleeding critically ill adult patients and identifies areas where further research is needed.

Variation in prophylactic tranexamic acid administration among anesthesiologists and surgeons in orthopedic surgery: a retrospective cohort study

The routine use of TXA in primary THA was confirmed, while observing lower utilization with more variability in hip fracture and spine fusion surgery, and the barriers to TXA implementation in a broader population of orthopedic surgical patients at high risk for transfusion.

Prehospital Resuscitation

Tranexamic acid in emergency care.

  • B. Bloom
  • Medicine
    European journal of emergency medicine : official journal of the European Society for Emergency Medicine
  • 2020
There are more than 70 trials of TXA in surgical situations, and almost all show a positive treatment effect to reduce bleeding, but most are also small, recruiting fewer than 200 patients.

Actualités en médecine d’urgence

Patient blood management

A short review of recent developments in the field of patient blood management (PBM), a patient‐centred and multidisciplinary approach to manage anaemia, minimize iatrogenic blood loss and harness tolerance to anaemia to improve patient outcome.

Tranexamic acid in traumatic intracranial bleeding: recognizing the limit of results (of the CRASH-3 trial).

  • E. Heymann
  • Medicine
    European journal of emergency medicine : official journal of the European Society for Emergency Medicine
  • 2019
The CRASH-3 study aimed to answer the question of will the drug be beneficial to a more common presentation of everyday Emergency Medicine, that is, the intracranial bleed with a large international multicentre randomized (placebo) controlled trial.

Tranexamic Acid for Acute Hemorrhage: When Is Enough Evidence Enough?

A critical reappraisal of tranexamic acid (TXA) utilization over the past decade is presented and their opinion of the potential downsides of a liberal usage of TXA is summarized and they advocate for a more selective and individualized TXA use based on viscoelastic hemostatic assays for real-time assessment of fibrinolysis.

Review of massive transfusion protocols in the injured, bleeding patient.

There is evidence that higher plasma to RBC ratios correlate with improved survival, and that adjuncts to transfusion play a key role, and recent validations of massive haemorrhage scoring systems should allow more consistent and appropriate triggering of massive transfusions.