Trandolapril does not improve insulin sensitivity in patients with hypertension and type 2 diabetes: a double-blind, placebo-controlled crossover trial.

@article{Petrie2000TrandolaprilDN,
  title={Trandolapril does not improve insulin sensitivity in patients with hypertension and type 2 diabetes: a double-blind, placebo-controlled crossover trial.},
  author={John R Petrie and Andrew D. Morris and Shinichiro Ueda and Margaret Small and Ronan Donnelly and John M. Connell and Henry L. Elliott},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2000},
  volume={85 5},
  pages={
          1882-9
        }
}
Angiotensin-converting enzyme (ACE) inhibitors are increasingly used as first-line therapy for hypertension in type 2 diabetes mellitus and are widely believed to improve insulin sensitivity (M). However, the evidence for the latter effect does not stand close scrutiny. We have assessed the effect of the ACE inhibitor trandolapril on M in 16 patients (mean +/- SD age, 58 +/- 10.6 yr) with mild-to-moderate essential hypertension (initial blood pressure, 173 +/- 14.5/93 +/- 8.0 mm Hg), obesity… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 16 CITATIONS

Microvascular dysfunction and the development of muscle insulin resistance

VIEW 5 EXCERPTS
CITES BACKGROUND & RESULTS
HIGHLY INFLUENCED

The Role of the Angiotensin System in Cardiac Glucose Homeostasis

E. Bernobich, Luisa de Angelis, Carlos Lerin, Giuseppe Bellini
  • Drugs
  • 2002
VIEW 3 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED