Tramesan, a novel polysaccharide from Trametes versicolor. Structural characterization and biological effects

Abstract

Mushrooms represent a formidable source of bioactive compounds. Some of these may be considered as biological response modifiers; these include compounds with a specific biological function: antibiotics (e.g. plectasin), immune system stimulator (e,g, lentinan), antitumor agents (e.g. krestin, PSK) and hypolipidemic agents (e.g. lovastatin) inter alia. In this study, we focused on the Chinese medicinal mushroom "yun zhi", Trametes versicolor, traditionally used for (cit.) "replenish essence and qi (vital energy)". Previous studies indicated the potential activity of extracts from culture filtrate of asexual mycelia of T. versicolor in controlling the growth and secondary metabolism (e.g. mycotoxins) of plant pathogenic fungi. The quest of active principles produced by T. versicolor, allowed us characterising an exo-polysaccharide released in its culture filtrate and naming it Tramesan. Herein we evaluate the biological activity of Tramesan in different organisms: plants, mammals and plant pathogenic fungi. We suggest that the bioactivity of Tramesan relies mostly on its ability to act as pro antioxidant molecule regardless the biological system on which it was applied.

DOI: 10.1371/journal.pone.0171412

8 Figures and Tables

Cite this paper

@inproceedings{Scarpari2017TramesanAN, title={Tramesan, a novel polysaccharide from Trametes versicolor. Structural characterization and biological effects}, author={Marzia Scarpari and Massimo Reverberi and Alessia Parroni and Valeria Scala and Corrado Fanelli and Chiara Pietricola and Slaven Zjalic and Vittoria Maresca and Agostino Tafuri and Maria Rosaria Ricciardi and Roberto Licchetta and Simone Mirabilii and Aris Sveronis and Paola Cescutti and Roberto Giorgio Rizzo}, booktitle={PloS one}, year={2017} }