Tramadol induces antidepressant-type effects in mice.

  title={Tramadol induces antidepressant-type effects in mice.},
  author={Mar{\'i}a Olga Rojas-Corrales and Juan Gibert-Rahola and Juan Antonio Mic{\'o}},
  journal={Life sciences},
  volume={63 12},
Tramadol is a clinically-effective, centrally-acting analgesic. This drug is a racemic mixture of two enantiomers, each one displaying different mechanisms: (+)tramadol displays opioid agonist properties and inhibits serotonin reuptake while (-)tramadol inhibit preferentially noradrenaline reuptake. The action of tramadol on the monoaminergic reuptake is similar to that of antidepressant drugs. Therefore, we have examined the effects of (+/-)tramadol, (+)tramadol and (-)tramadol in a test… CONTINUE READING


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