Tramadol for the treatment of fibromyalgia

@article{Maclean2015TramadolFT,
  title={Tramadol for the treatment of fibromyalgia},
  author={Ashley J B Maclean and Thomas L. Schwartz},
  journal={Expert Review of Neurotherapeutics},
  year={2015},
  volume={15},
  pages={469 - 475}
}
Tramadol is a novel, synthetic opioid receptor agonist with serotonin-norepinephrine reuptake inhibitor properties that is often prescribed acutely for painful conditions. Fibromyalgia (FM) is a chronic painful condition that is difficult to treat and until more recently has had no approved medical treatments. Currently, the only US FDA-approved medications for FM include duloxetine, milnacipran and pregabalin. No opioid is approved for use in the treatment of FM. This paper specifically… 
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References

SHOWING 1-10 OF 55 REFERENCES
The use of opioids in fibromyalgia
TLDR
There is insufficient evidence to recommend the routine use of opioids in FMS, and their inefficacy may be due to their inability to target the pathophysiologic processes involved in this central sensitization syndrome.
Milnacipran for fibromyalgia: a useful addition to the treatment armamentarium
TLDR
Milnacipran provides modest fibromyalgia pain relief and is best used as part of a multidisciplinary treatment approach and may be a wise choice for Fibromyalgia patients with depressive symptoms and patients for whom sedation, dizziness, edema or weight gain with gabapentin and pregabalin is a problem.
[Tramadol/acetaminophen combination tablets].
TLDR
It is expected that Tramset is going to induce pain relief and to improve disturbance of daily life in patients with intractable chronic pain, however overuse of Tram set may induce severe adverse effects such as addiction, abuse and hepatotoxicity.
Review of pharmacological therapies in fibromyalgia syndrome
This review addresses the current status of drug therapy for the management of fibromyalgia syndrome (FMS) and is based on interdisciplinary FMS management guidelines, meta-analyses of drug trial
Oxycodone for neuropathic pain and fibromyalgia in adults.
TLDR
Oxycodone is a strong opioid agonist widely used to manage severe pain; this review assesses evidence for oxycodone using current standards of evidence designed to reduce bias.
Tramadol in the fibromyalgia syndrome: a controlled clinical trial versus placebo.
TLDR
The contrasting results found in the present study could be a stimulus for the organization of new projects, which may lead to the identification of an optimal therapeutic approach for fibromyalgic patients, also using tramadol for long periods.
Opioid Use in Fibromyalgia Is Associated with Negative Health Related Measures in a Prospective Cohort Study
TLDR
In this first study reporting on health related measures and opioid use in FM, opioid users had poorer symptoms and functional and occupational status compared to nonusers and there is no evidence that these agents improved status beyond standard care.
Pharmacotherapy for Fibromyalgia
TLDR
The potential theories that possibly contribute to the pathogenesis of FM will be discussed, and a clinical algorithm will be presented for the step-wise management of pain and other associated symptoms of FM.
The hypoalgesic effect of tramadol in relation to CYP2D6 *
The Efficacy and Safety of Milnacipran for Treatment of Fibromyalgia. A Randomized, Double-blind, Placebo-controlled Trial
TLDR
Milnacipran was safe and well tolerated by the majority of patients during 27 weeks of treatment; nausea and headache were the most common adverse events.
...
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