Tramadol and Its Metabolite M1 Selectively Suppress Transient Receptor Potential Ankyrin 1 Activity, but Not Transient Receptor Potential Vanilloid 1 Activity

@article{Miyano2015TramadolAI,
  title={Tramadol and Its Metabolite M1 Selectively Suppress Transient Receptor Potential Ankyrin 1 Activity, but Not Transient Receptor Potential Vanilloid 1 Activity},
  author={Kanako Miyano and Kouichiro Minami and Toru Yokoyama and Katsuya Ohbuchi and Takuhiro Yamaguchi and Satoshi Murakami and Seiji Shiraishi and Masahiro Yamamoto and Motohiro Matoba and Yasuhito Uezono},
  journal={Anesthesia \& Analgesia},
  year={2015},
  volume={120},
  pages={790–798}
}
BACKGROUND:The transient receptor potential vanilloid 1 (TRPV1) and the transient receptor potential ankyrin 1 (TRPA1), which are expressed in sensory neurons, are polymodal nonselective cation channels that sense noxious stimuli. Recent reports showed that these channels play important roles in inflammatory, neuropathic, or cancer pain, suggesting that they may serve as attractive analgesic pharmacological targets. Tramadol is an effective analgesic that is widely used in clinical practice… 
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