Tramadol Sustained-Release Capsules

@article{Keating2012TramadolSC,
  title={Tramadol Sustained-Release Capsules},
  author={Gillian M. Keating},
  journal={Drugs},
  year={2012},
  volume={66},
  pages={223-230}
}
Abstract▴ Tramadol is a synthetic, centrally acting analgesic. A sustained-release (SR) capsule formulation of tramadol gradually releases active drug, allowing for twice-daily dosing.▴ Compared with tramadol SR tablets, tramadol SR capsules produced a smoother plasma concentration profile, with more gradual absorption and lower peak concentrations. There was less intra- and inter-subject variability in tramadol plasma concentrations with SR capsules versus SR tablets.▴ Tramadol SR capsules had… 
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Although tramadol SR capsules and tramadl SR tablets led to an equivalent systemic exposure to the drug, capsules provided a smoother and more extended plasma profile.
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TLDR
The study demonstrated that tramadol provides adequate pain relief in patients with chronic low back pain and tramadl administered as sustained-release capsules was better tolerated than the reference product.
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The investigation showed an only slightly diminished bioavailability of the tramadol sustained release capsules compared to the instant release formulation and enhanced retardation at almost identical bioavailability compared with the sustained release competitor drug.
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Pharmacokinetic properties of tramadol sustained release capsules. 3rd communication: investigation of relative bioavailability under steady state conditions.
TLDR
A bioavailability of 100% for the sustained release capsules compared with the instant release capsules was obtained and statistical analysis of the peak trough fluctuation at steady state PTFss yielded a distinct diminution of the fluctuation.
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The instauration of tramadol treatment, starting with sustained-release 50mg capsules twice daily and escalating the dose some days later to 100mg twice daily, was shown to be an effective and easy way to improve tramadols tolerability in clinical practice, whilst maintaining its analgesic efficacy.
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Pharmacokinetic properties of tramadol sustained release capsules: 1st commuE-mail: demail@adis.co.nz
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