Tramadol Sustained-Release Capsules

  title={Tramadol Sustained-Release Capsules},
  author={Gillian M. Keating},
Abstract▴ Tramadol is a synthetic, centrally acting analgesic. A sustained-release (SR) capsule formulation of tramadol gradually releases active drug, allowing for twice-daily dosing.▴ Compared with tramadol SR tablets, tramadol SR capsules produced a smoother plasma concentration profile, with more gradual absorption and lower peak concentrations. There was less intra- and inter-subject variability in tramadol plasma concentrations with SR capsules versus SR tablets.▴ Tramadol SR capsules had… 
Tramadol Extended-Release Tablets
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Tramadol SR Formulations
Although tramadol SR capsules and tramadl SR tablets led to an equivalent systemic exposure to the drug, capsules provided a smoother and more extended plasma profile.
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Pharmacokinetic properties of tramadol sustained release capsules: 1st commuE-mail:
  • Adis Data Information BV. All rights reserved. Drugs
  • 2006
Tramadol SR formulations: escalation schedule on tramadol tolerability: assessment in the pharmacokinetic comparison of a multiple-units dose (capsule) clinical setting
  • Clin Drug Invest
  • 2005