Tramadol, but not its major metabolite (mono-O-demethyl tramadol) depresses compound action potentials in frog sciatic nerves.

@article{Katsuki2006TramadolBN,
  title={Tramadol, but not its major metabolite (mono-O-demethyl tramadol) depresses compound action potentials in frog sciatic nerves.},
  author={R Katsuki and Tsugumi Fujita and Akiko Koga and Tao Liu and Terumasa Nakatsuka and Mikio Nakashima and Eiichi Kumamoto},
  journal={British journal of pharmacology},
  year={2006},
  volume={149 3},
  pages={319-27}
}
BACKGROUND AND PURPOSE Although tramadol is known to exhibit a local anaesthetic effect, how tramadol exerts this effect is not understood fully. EXPERIMENTAL APPROACH The effects of tramadol and its metabolite mono-O-demethyl-tramadol (M1) on compound action potentials (CAPs) were examined by applying the air-gap method to frog sciatic nerves, and the results were compared with those of other local anaesthetics, lidocaine and ropivacaine. KEY RESULTS Tramadol reduced the peak amplitude of… CONTINUE READING

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