Tramadol, a centrally acting opioid: anticonvulsant effect against maximal electroshock seizure in mice.

@article{Manocha1998TramadolAC,
  title={Tramadol, a centrally acting opioid: anticonvulsant effect against maximal electroshock seizure in mice.},
  author={Anshu Manocha and Krishna Kishore Sharma and Pramod Kumari Mediratta},
  journal={Indian journal of physiology and pharmacology},
  year={1998},
  volume={42 3},
  pages={407-11}
}
The present study was designed to investigate the pro- or anticonvulsant effect of tramadol using maximal electroshock (MES) test. An attempt was also made to determine the possible opioid receptor mechanism involved. MES seizures were induced through transauricular electrodes (60 mA, 0.2s) and the seizure severity was assessed by the duration of tonic hindlimb extensor phase. Intraperitoneal (i.p.) administration of tramadol resulted in a dose-dependent anticonvulsant action; the ED50 for the… CONTINUE READING