Trajectories of inflammatory markers and cognitive decline over 10 years.

  title={Trajectories of inflammatory markers and cognitive decline over 10 years.},
  author={Andrea L Metti and Kristine Yaffe and Robert T M Boudreau and Eleanor M. Simonsick and Ryan M Carnahan and Suzanne Satterfield and Tamara B. Harris and Hilsa N. Ayonayon and Caterina Rosano and Jane A. Cauley},
  journal={Neurobiology of aging},
  volume={35 12},
We aimed to examine trajectories of inflammatory markers and cognitive decline over 10 years. Cox proportional hazards models were used to examine the association between interleukin-6 and C-reactive protein (CRP) trajectory components (slope, variability, and baseline level) and cognitive decline among 1323 adults, aged 70-79 years in the Health, Aging, and Body Composition Study. We tested for interactions by sex and apolipoprotein E (APOE) genotype. In models adjusted for multiple covariates… CONTINUE READING
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