Trajectories and nuclear arrangement of PML bodies are influenced by A-type lamin deficiency.

@article{Stixov2012TrajectoriesAN,
  title={Trajectories and nuclear arrangement of PML bodies are influenced by A-type lamin deficiency.},
  author={Lenka Stixov{\'a} and Pavel Matula and S. Horneck G. Kozubek and Adri{\'a}na Gombitov{\'a} and Du{\vs}an Cmarko and Ivan Raska and Eva B{\'a}rtov{\'a}},
  journal={Biology of the cell},
  year={2012},
  volume={104 7},
  pages={
          418-32
        }
}
BACKGROUND INFORMATION Promyelocytic leukaemia (PML) bodies are specific nuclear structures with functional significance for acute promyelocytic leukaemia. In this study, we analysed the trajectories of PML bodies using single-particle tracking. RESULTS We observed that the recovery of PML protein after photobleaching was ATP dependent in both wild-type (wt) and A-type lamin-deficient cells. The movement of PML bodies was faster and the nuclear area occupied by particular PML bodies was… CONTINUE READING
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