Trait stacking via targeted genome editing.

@article{Ainley2013TraitSV,
  title={Trait stacking via targeted genome editing.},
  author={William Michael Ainley and Lakshmi Sastry-Dent and Mary E Welter and Michael G. Murray and Bryan Zeitler and Rainier Amora and David R Corbin and Rebecca R. Miles and Nicole L. Arnold and Tonya L Strange and Matthew A. Simpson and Zehui Cao and Carley Carroll and Katherine S Pawelczak and R. Blue and K. F. West and Lynn M Rowland and Douglas Perkins and Pon Samuel and Cristie M Dewes and Liu Shen and Shreedharan Sriram and Steven L. Evans and Edward J. Rebar and Lei Zhang and Phillip D Gregory and Fyodor D. Urnov and Steven R Webb and Joseph F. Petolino},
  journal={Plant biotechnology journal},
  year={2013},
  volume={11 9},
  pages={1126-34}
}
Modern agriculture demands crops carrying multiple traits. The current paradigm of randomly integrating and sorting independently segregating transgenes creates severe downstream breeding challenges. A versatile, generally applicable solution is hereby provided: the combination of high-efficiency targeted genome editing driven by engineered zinc finger nucleases (ZFNs) with modular 'trait landing pads' (TLPs) that allow 'mix-and-match', on-demand transgene integration and trait stacking in crop… CONTINUE READING
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