Trait-Associated SNPs Are More Likely to Be eQTLs: Annotation to Enhance Discovery from GWAS

@inproceedings{Nicolae2010TraitAssociatedSA,
  title={Trait-Associated SNPs Are More Likely to Be eQTLs: Annotation to Enhance Discovery from GWAS},
  author={Dan L. Nicolae and Eric R. Gamazon and Wei Zhang and Shiwei Duan and M. Eileen Dolan and Nancy J. Cox},
  booktitle={PLoS genetics},
  year={2010}
}
Although genome-wide association studies (GWAS) of complex traits have yielded more reproducible associations than had been discovered using any other approach, the loci characterized to date do not account for much of the heritability to such traits and, in general, have not led to improved understanding of the biology underlying complex phenotypes. Using a web site we developed to serve results of expression quantitative trait locus (eQTL) studies in lymphoblastoid cell lines from HapMap… CONTINUE READING
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