Training the "less-affected" forelimb after unilateral cortical infarcts interferes with functional recovery of the impaired forelimb in rats.

@article{Allred2005TrainingT,
  title={Training the "less-affected" forelimb after unilateral cortical infarcts interferes with functional recovery of the impaired forelimb in rats.},
  author={Rachel Patrice Allred and M{\'o}nica Alexandra Arias Maldonado and J E Hsu And and Theresa A. Jones},
  journal={Restorative neurology and neuroscience},
  year={2005},
  volume={23 5-6},
  pages={297-302}
}
PURPOSE Unilateral lesions of the sensorimotor cortex (SMC) in adult rats cause major behavioral changes in the ipsilesional, "less-affected" forelimb. An increase in function and reliance on this forelimb can aid compensation for contralesional impairments, but may also promote disuse and reduced functionality of the impaired forelimb. We hypothesized that training focused on the ipsilesional forelimb following a unilateral SMC lesion would reduce the efficacy of later motor rehabilitative… CONTINUE READING

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