Trained immunity in newborn infants of HBV-infected mothers


The newborn immune system is characterized by an impaired Th1-associated immune response. Hepatitis B virus (HBV) transmitted from infected mothers to newborns is thought to exploit the newborns' immune system immaturity by inducing a state of immune tolerance that facilitates HBV persistence. Contrary to this hypothesis, we demonstrate here that HBV… (More)
DOI: 10.1038/ncomms7588


Cite this paper

@inproceedings{Hong2015TrainedII, title={Trained immunity in newborn infants of HBV-infected mothers}, author={Michelle Li Wen Hong and Elena Sandalova and Diana H. P. Low and Adam J. Gehring and Stefania Fieni and Barbara Amadei and Simonetta Urbani and Yap-Seng Chong and Ernesto Guccione and Antonio Bertoletti}, booktitle={Nature communications}, year={2015} }