Trail interacts redundantly with nitric oxide in rat astrocytes: Potential contribution to neurodegenerative processes

@article{Cantarella2007TrailIR,
  title={Trail interacts redundantly with nitric oxide in rat astrocytes: Potential contribution to neurodegenerative processes},
  author={Giuseppina Cantarella and Laurence Lempereur and Maria Antonia D'Alcamo and Nunziata Risuglia and Renato Bernardini},
  journal={Journal of Neuroimmunology},
  year={2007},
  volume={182},
  pages={41-47}
}
The proapoptotic cytokine TRAIL has been shown to enhance amyloid-beta-dependent neurotoxicity. Here are reported interactions between TRAIL and nitric oxide (NO) in cultured rat astrocytes in vitro. Rat astrocytes expressed all TRAIL receptor mRNAs and proteins. However, TRAIL failed in inducing apoptosis of astrocytes, whereas these cells released substantial amounts of nitrites. A TRAIL-neutralizing antibody was able to prevent LPS-induced iNOS expression in astrocytes. Interestingly, TRAIL… CONTINUE READING
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