Trail-induced apoptosis in Type I leukemic cells is not enhanced by overexpression of bax.

@article{Jia2001TrailinducedAI,
  title={Trail-induced apoptosis in Type I leukemic cells is not enhanced by overexpression of bax.},
  author={Li Jia and Yasmeen Patwari and Stephen M. Kelsey and Adrian C. Newland},
  journal={Biochemical and biophysical research communications},
  year={2001},
  volume={283 5},
  pages={1037-45}
}
We have previously shown that Bax translocation was crucial in TNFalpha or etoposide-induced apoptosis. Overexpression of Bax sensitized chronic myeloid leukemic K562 cells to etoposide-induced apoptosis. Treatment with TNF-related apoptosis-inducing ligand (TRAIL) induces a loss of mitochondrial membrane potential (DeltaPsim), cytochrome c release from mitochondria, activation of caspases-8, -9, and -3, and cleavage of Bid in the K562 cell line. Bax failed to sensitize K562 cells to TRAIL… CONTINUE READING

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