Trafficking of phosphatidylinositol by phosphatidylinositol transfer proteins.
@article{Cockcroft2007TraffickingOP, title={Trafficking of phosphatidylinositol by phosphatidylinositol transfer proteins.}, author={Shamshad Cockcroft}, journal={Biochemical Society symposium}, year={2007}, volume={74}, pages={ 259-71 } }
PtdIns is synthesized at the endoplasmic reticulum and its intracellular distribution to other organelles can be facilitated by lipid transfer proteins [PITPs (phosphatidylinositol transfer proteins)]. In this review, I summarize the current understanding of how PITPs are regulated by phosphorylation, how can they dock to membranes to exchange their lipid cargo and how cells use PITPs in signal transduction and membrane delivery. Mammalian PITPs, PITPalpha and PITPbeta, are paralogous genes…
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