Trafficking of membrane proteins to cone but not rod outer segments is dependent on heterotrimeric kinesin-II.

@article{Avasthi2009TraffickingOM,
  title={Trafficking of membrane proteins to cone but not rod outer segments is dependent on heterotrimeric kinesin-II.},
  author={Prachee Avasthi and Carl B. Watt and David S Williams and Yun Zheng Le and Sha Li and C Chen and Robert E. Marc and Jeanne M. Frederick and Wolfgang Baehr},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2009},
  volume={29 45},
  pages={14287-98}
}
Heterotrimeric kinesin-II is a molecular motor localized to the inner segment, connecting cilium and axoneme of mammalian photoreceptors. Our purpose was to identify the role of kinesin-II in anterograde intraflagellar transport by photoreceptor-specific deletions of kinesin family member 3A (KIF3A), its obligatory motor subunit. In cones lacking KIF3A, membrane proteins involved in phototransduction did not traffic to the outer segments resulting in complete absence of a photopic… CONTINUE READING

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