Trafficking of heme and porphyrins in metazoa.

  title={Trafficking of heme and porphyrins in metazoa.},
  author={Scott Severance and Iqbal Hamza},
  journal={Chemical reviews},
  volume={109 10},
A half century ago, Max Perutz and John Kendrew determined the crystal structure of two heme-containing proteins: hemoglobin and myoglobin, respectively.1,2 These landmark discoveries created the foundation for a detailed biochemical understanding of how protein structure influences and affects its ability to bind and carry oxygen. Perutz and Kendrew were awarded the Nobel Prize in 1962. Since then, scores of hemoprotein structures have been solved, although the mechanisms and molecules… CONTINUE READING

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