Trafficking of TRPP2 by PACS proteins represents a novel mechanism of ion channel regulation.

  title={Trafficking of TRPP2 by PACS proteins represents a novel mechanism of ion channel regulation.},
  author={Michael K{\"o}ttgen and Thomas Benzing and Thomas Simmen and Robert Tauber and Bj{\"o}rn Buchholz and Sylvain F. Feliciangeli and Tobias B Huber and Bernhard Schermer and Albrecht Kramer-Zucker and Katja Hoepker and Katia Carmine Simmen and Christoph Carl Tschucke and Richard Sandford and Emily Rosenthal ‐ Kim and Gary Thomas and Gerd Walz},
  journal={The EMBO journal},
  volume={24 4},
The trafficking of ion channels to the plasma membrane is tightly controlled to ensure the proper regulation of intracellular ion homeostasis and signal transduction. Mutations of polycystin-2, a member of the TRP family of cation channels, cause autosomal dominant polycystic kidney disease, a disorder characterized by renal cysts and progressive renal failure. Polycystin-2 functions as a calcium-permeable nonselective cation channel; however, it is disputed whether polycystin-2 resides and… CONTINUE READING
95 Citations
52 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 95 extracted citations


Publications referenced by this paper.
Showing 1-10 of 52 references

Similar Papers

Loading similar papers…