Trafficking of NMDA receptors.

  title={Trafficking of NMDA receptors.},
  author={Robert J. Wenthold and Kate Prybylowski and Steve Standley and Nathalie Sans and Ronald S. Petralia},
  journal={Annual review of pharmacology and toxicology},
The NMDA receptor (NMDAR) plays a central role in the function of excitatory synapses. Recent studies have provided interesting insights into several aspects of the trafficking of this receptor in neurons. The NMDAR is not a static resident of the synapse. Rather, the number and composition of synaptic NMDARs can be modulated by several factors. The interaction of PDZ proteins, generally thought to occur at the synapse, appears to occur early in the secretory pathway; this interaction may play… CONTINUE READING
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