Trafficking of G-protein-coupled receptors to the plasma membrane: insights for pharmacoperone drugs.

Abstract

G protein-coupled receptors (GPCRs) are among the most common potential targets for pharmacological design. Synthesized in the endoplasmic reticulum, they interact with endogenous chaperones that assist in folding (or can retain incorrectly folded proteins) and are transferred to the plasma membrane where they exert their physiological functions. We… (More)
DOI: 10.1016/j.tem.2009.11.003

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Cite this paper

@article{Conn2010TraffickingOG, title={Trafficking of G-protein-coupled receptors to the plasma membrane: insights for pharmacoperone drugs.}, author={P. Michael Conn and Alfredo Ulloa-Aguirre}, journal={Trends in endocrinology and metabolism: TEM}, year={2010}, volume={21 3}, pages={190-7} }