Trafficking of ENaC subunits in response to acute insulin in mouse kidney.

@article{Tiwari2007TraffickingOE,
  title={Trafficking of ENaC subunits in response to acute insulin in mouse kidney.},
  author={Swasti Tiwari and Lina Nordquist and Veerendra Kumar Madala Halagappa and Carolyn M A Ecelbarger},
  journal={American journal of physiology. Renal physiology},
  year={2007},
  volume={293 1},
  pages={
          F178-85
        }
}
Studies done in cell culture have demonstrated that insulin activates the epithelial sodium channel (ENaC) via a variety of mechanisms. However, to date, upregulation of ENaC in native renal tissue by in vivo administration of insulin has not been demonstrated. To address this, we injected 6-mo-old male C57BL/CBA mice (n = 14/group) intraperitoneally with vehicle or 0.5 U/kg body wt insulin and examined short-term (1-2 h) sodium excretion and kidney ENaC subunits (alpha, beta, and gamma) and… CONTINUE READING

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