Trafficking between glia and neurons of TCA cycle intermediates and related metabolites.

  title={Trafficking between glia and neurons of TCA cycle intermediates and related metabolites.},
  author={Arne Schousboe and Niels Westergaard and Helle S\onderby Waagepetersen and Orla Miller Larsson and Inger J Bakken and Ursula Sonnewald},
  volume={21 1},
Net synthesis of the neurotransmitter amino acids glutamate and GABA can take place either from glutamine or from alpha-ketoglutarate or another tricarboxylic acid (TCA) cycle intermediate plus an amino acid as donor of the amino group. Since neurons lack the enzymes glutamine synthetase and pyruvate carboxylase that are expressed only in astrocytes, trafficking of these metabolites must take place between neurons and astrocytes. Moreover, it is likely that astrocytes play an important role in… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 79 extracted citations

Newer aspects of glutamine/glutamate metabolism: the role of acute pH changes.

The American journal of physiology • 1999
View 7 Excerpts
Highly Influenced

Characterization of the L-glutamate clearance pathways across the blood-brain barrier and the effect of astrocytes in an in vitro blood-brain barrier model.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism • 2017

Similar Papers

Loading similar papers…