Trafficking between glia and neurons of TCA cycle intermediates and related metabolites.

@article{Schousboe1997TraffickingBG,
  title={Trafficking between glia and neurons of TCA cycle intermediates and related metabolites.},
  author={Arne Schousboe and Niels Westergaard and Helle S\onderby Waagepetersen and Orla Miller Larsson and Inger J Bakken and Ursula Sonnewald},
  journal={Glia},
  year={1997},
  volume={21 1},
  pages={99-105}
}
Net synthesis of the neurotransmitter amino acids glutamate and GABA can take place either from glutamine or from alpha-ketoglutarate or another tricarboxylic acid (TCA) cycle intermediate plus an amino acid as donor of the amino group. Since neurons lack the enzymes glutamine synthetase and pyruvate carboxylase that are expressed only in astrocytes, trafficking of these metabolites must take place between neurons and astrocytes. Moreover, it is likely that astrocytes play an important role in… CONTINUE READING

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