Trafficking and signaling by fatty-acylated and prenylated proteins.

  title={Trafficking and signaling by fatty-acylated and prenylated proteins.},
  author={Marilyn D. Resh},
  journal={Nature chemical biology},
  volume={2 11},
A wide variety of signaling proteins are modified by covalently linked fatty acids and/or prenyl groups. These hydrophobic moieties, which include myristate, palmitate, farnesyl and geranylgeranyl, are more than just fat: they provide distinct information that modulates the specificity and efficiency of signal transduction. Recent studies show that lipid modification influences the movement of a signaling protein within the cell and its final destination. Protein lipidation can also confer… CONTINUE READING
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