Trafficking and replication patterns reveal splenic macrophages as major targets of dengue virus in mice.

Abstract

Human postmortem studies of natural dengue virus (DENV) infection have reported systemically distributed viral antigen. Although it is widely accepted that DENV infects mononuclear phagocytes, the sequence in which specific tissues and cell types are targeted remains uncharacterized. We previously reported that mice lacking alpha/beta and gamma interferon… (More)
DOI: 10.1128/JVI.00375-12

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