Trafficking and fusion of neuropeptide Y-containing dense-core granules in astrocytes.

@article{Ramamoorthy2008TraffickingAF,
  title={Trafficking and fusion of neuropeptide Y-containing dense-core granules in astrocytes.},
  author={Prabhu Ramamoorthy and Matthew D. Whim},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2008},
  volume={28 51},
  pages={13815-27}
}
It is becoming clear that astrocytes are active participants in synaptic functioning and exhibit properties, such as the secretion of classical transmitters, previously thought to be exclusively neuronal. Whether these similarities extend to the release of neuropeptides, the other major class of transmitters, is less clear. Here we show that cortical astrocytes can synthesize both native and foreign neuropeptides and can secrete them in a stimulation-dependent manner. Reverse transcription-PCR… CONTINUE READING