Trafficking and cell surface stability of ENaC.

  title={Trafficking and cell surface stability of ENaC.},
  author={Daniela Rotin and Voula Kanelis and Laurent Schild},
  journal={American journal of physiology. Renal physiology},
  volume={281 3},
The epithelial Na(+) channel (ENaC) plays a key role in the regulation of Na(+) and water absorption in several epithelia, including those of the distal nephron, distal colon, and lung. Accordingly, mutations in ENaC leading to reduced or increased channel activity cause human diseases such as pseudohypoaldosteronism type I or Liddle's syndrome, respectively. The gain of ENaC function in Liddle's syndrome is associated with increased activity and stability of the channel at the plasma membrane… CONTINUE READING
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