Traffic-related PM2.5 induces cytosolic [Ca²⁺] increase regulated by Orai1, alters the CaN-NFAT signaling pathway, and affects IL-2 and TNF-α cytoplasmic levels in Jurkat T-cells.

@article{Tong2015TrafficrelatedPI,
  title={Traffic-related PM2.5 induces cytosolic [Ca²⁺] increase regulated by Orai1, alters the CaN-NFAT signaling pathway, and affects IL-2 and TNF-α cytoplasmic levels in Jurkat T-cells.},
  author={Guo-Qiang Tong and Zhi-hong Zhang and Ying Ming Zhao and Jie-Jing Liu and Jian-Biao Han},
  journal={Archives of environmental contamination and toxicology},
  year={2015},
  volume={68 1},
  pages={31-7}
}
The atmospheric particulate matter with a diameter less than or equal to 2.5 um (PM2.5) can result in increased immune system damage or diseases, however, the possible mechanism remains unclear. In this study, we used Jurkat T cells to determine the effects of PM2.5 on T cell-mediated adaptive immune response. Our results indicated that PM2.5 exposure increased intracellular calcium ion concentration [Ca(2+)]. In contrast, cytosolic free Ca(2+) concentration [Ca(2+)]i significantly decreased in… CONTINUE READING