Traditional multiplicity adjustment methods in clinical trials.

  title={Traditional multiplicity adjustment methods in clinical trials.},
  author={Alex Dmitrienko and Ralph B. D'Agostino},
  journal={Statistics in medicine},
  volume={32 29},
This tutorial discusses important statistical problems arising in clinical trials with multiple clinical objectives based on different clinical variables, evaluation of several doses or regiments of a new treatment, analysis of multiple patient subgroups, etc. Simultaneous assessment of several objectives in a single trial gives rise to multiplicity. If… CONTINUE READING