Traditional and non-traditional uses of Mitragynine (Kratom): A survey of the literature

@article{Singh2016TraditionalAN,
  title={Traditional and non-traditional uses of Mitragynine (Kratom): A survey of the literature},
  author={Darshan Singh and Suresh Narayanan and Balasingam Kasinather Vicknasingam},
  journal={Brain Research Bulletin},
  year={2016},
  volume={126},
  pages={41-46}
}
Kratom (Mitragyna speciosa): worldwide issues.
PURPOSE OF REVIEW To inform readers about the increasingly popular Western dietary supplement, kratom (Mitragyna speciosa) and how the products are available in the Western world compared with
Effects of Kratom (Mitragyna Speciosa Korth.) Use in Regular Users
TLDR
Daily kratom use produced both stimulant and sedative effects but they were not statistically significantly associated with the dose consumed, both among short-term and long-term users in the authors' sample.
Current and Future Potential Impact of COVID-19 on Kratom (Mitragyna speciosa Korth.) Supply and Use
TLDR
A shortage in the supply of kratom products may place unexpected burdens on kratom users, potentially influencing some who use kratom for SUD self-treatment to regress to harmful drug use, hence increasing the likelihood of adverse outcomes, including overdose.
Effect of regular kratom (Mitragyna speciosa Korth.) use on quality of life of people who use kratom
TLDR
Prolonged kratom use and kratom dependence may negatively impact the quality of life (QoL) of people who use kratom, hence kratom addiction has to be treated adequately.
Update on the Pharmacology and Legal Status of Kratom
  • W. Prozialeck
  • Environmental Science
    The Journal of the American Osteopathic Association
  • 2016
TLDR
This report highlights the current scientific and legal controversies regarding kratom and its mitragynine constituents, which prompted a massive response from kratom advocates.
Current perspectives on the impact of Kratom use
TLDR
It is notable that Kratom can cause herb–drug interactions, especially with other central nervous system -active substances, and consumers may be exposed to adulterated or contaminated products, especially if purchased through websites or the darknet.
The Use of Kratom (Mitragyna speciosa Korth.) Among People Who Co-use Heroin and Methamphetamine in Malaysia
TLDR
The potential of kratom to alleviate heroin withdrawal symptoms, and to reduce methamphetamine and heroin intake, among people who co-use heroin and methamphetamine warrants further research.
Kratom use and mental health: A systematic review.
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References

SHOWING 1-10 OF 44 REFERENCES
Experiences of Kratom Users: A Qualitative Analysis
Abstract Kratom (Mitragyna speciosa) is a psychoactive plant that has been used since at least 1836 in folk medicine in Southeast Asian countries. More recently, kratom has become widely available in
Following “the Roots” of Kratom (Mitragyna speciosa): The Evolution of an Enhancer from a Traditional Use to Increase Work and Productivity in Southeast Asia to a Recreational Psychoactive Drug in Western Countries
TLDR
It is concluded that the use of kratom is not negligible, especially for self-medication, and more clinical, pharmacological, and socioanthropological studies as well as a better international collaboration are needed to tackle this marginally explored phenomenon.
Social Functioning of Kratom (Mitragyna speciosa) Users in Malaysia
TLDR
It is suggested that chronic kratom administration does not significantly impair social functioning of users in a natural context in Malaysia, despite being dependent on kratom for prolonged periods of time.
The pharmacology and toxicology of kratom: from traditional herb to drug of abuse
TLDR
There are currently no standard analytical screening techniques for mitragynine and its metabolites following ingestion limiting its detection to more sophisticated techniques like liquid chromatography-mass spectrometry to determine kratom use.
Mitragyna speciosa use in the northern states of Malaysia: a cross-sectional study.
Kratom Abuse in Ramathibodi Poison Center, Thailand: A Five-Year Experience
TLDR
A retrospective review of Kratom exposure cases from the RPC toxic surveillance system found most cases in both groups had good prognostic outcome, and there was a baby with withdrawal symptoms who was delivered from a chronic Kratom-abusing mother, suggesting possible exposure via the transplacental route.
Kratom (Mitragyna speciosa) dependence, withdrawal symptoms and craving in regular users.
The Use of Mitragynine speciosa (“Krathom”), an Addictive Plant, in Thailand
TLDR
Patterns and consequences of chewing leaves of krathom, Mitragynine speciosa, Kroth.
A study of kratom eaters in Thailand.
TLDR
Thirty male and female cases of kratom addiction were selected from the Nondhaburi province and from the suburbs of Bangkok for the purpose of an intensive study, and the interview method was used with a questionnaire consisting of 30 items.
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