Traditional and Computational Screening of Non-Toxic Peptides and Approaches to Improving Selectivity

@article{RoblesLoaiza2022TraditionalAC,
  title={Traditional and Computational Screening of Non-Toxic Peptides and Approaches to Improving Selectivity},
  author={Alberto A Robles-Loaiza and Edgar A Pinos-Tamayo and Bruno Mendes and Josselyn A. Ortega-Pila and Carolina Proa{\~n}o-Bola{\~n}os and Fabien Plisson and C{\'a}tia Teixeira and Paula A C Gomes and Jos{\'e} Rafael Almeida},
  journal={Pharmaceuticals},
  year={2022},
  volume={15}
}
Peptides have positively impacted the pharmaceutical industry as drugs, biomarkers, or diagnostic tools of high therapeutic value. However, only a handful have progressed to the market. Toxicity is one of the main obstacles to translating peptides into clinics. Hemolysis or hemotoxicity, the principal source of toxicity, is a natural or disease-induced event leading to the death of vital red blood cells. Initial screenings for toxicity have been widely evaluated using erythrocytes as the gold… 

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