Traditional Biomolecular Structure Determination by NMR Spectroscopy Allows for Major Errors

@article{Nabuurs2006TraditionalBS,
  title={Traditional Biomolecular Structure Determination by NMR Spectroscopy Allows for Major Errors},
  author={Sander B. Nabuurs and Chris A. E. M. Spronk and Geerten W. Vuister and Gert Vriend},
  journal={PLoS Computational Biology},
  year={2006},
  volume={2},
  pages={249 - 265}
}
One of the major goals of structural genomics projects is to determine the three-dimensional structure of representative members of as many different fold families as possible. Comparative modeling is expected to fill the remaining gaps by providing structural models of homologs of the experimentally determined proteins. However, for such an approach to be successful it is essential that the quality of the experimentally determined structures is adequate. In an attempt to build a homology model… CONTINUE READING
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