Trading force for speed: why superfast crossbridge kinetics leads to superlow forces.

  title={Trading force for speed: why superfast crossbridge kinetics leads to superlow forces.},
  author={L C Rome and Charles Cook and Douglas A Syme and Martin A. Connaughton and Miriam A. Ashley-Ross and Anton Klimov and B A Tikunov and Yale E. Goldman},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={96 10},
Superfast muscles power high-frequency motions such as sound production and visual tracking. As a class, these muscles also generate low forces. Using the toadfish swimbladder muscle, the fastest known vertebrate muscle, we examined the crossbridge kinetic rates responsible for high contraction rates and how these might affect force generation. Swimbladder fibers have evolved a 10-fold faster crossbridge detachment rate than fast-twitch locomotory fibers, but surprisingly the crossbridge… CONTINUE READING


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