Tradeoffs and Optimality in the Evolution of Gene Regulation

@article{Poelwijk2011TradeoffsAO,
  title={Tradeoffs and Optimality in the Evolution of Gene Regulation},
  author={Frank J. Poelwijk and Marjon G. J. de Vos and Sander J. Tans},
  journal={Cell},
  year={2011},
  volume={146},
  pages={462-470}
}
Cellular regulation is believed to evolve in response to environmental variability. However, this has been difficult to test directly. Here, we show that a gene regulation system evolves to the optimal regulatory response when challenged with variable environments. We engineered a genetic module subject to regulation by the lac repressor (LacI) in E. coli, whose expression is beneficial in one environmental condition and detrimental in another. Measured tradeoffs in fitness between environments… CONTINUE READING
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