Tradeoff between enzyme and metabolite efficiency maintains metabolic homeostasis upon perturbations in enzyme capacity

@inproceedings{Fendt2010TradeoffBE,
  title={Tradeoff between enzyme and metabolite efficiency maintains metabolic homeostasis upon perturbations in enzyme capacity},
  author={Sarah-Maria Fendt and Joerg M. Buescher and Florian Rudroff and Paola Picotti and Nicola Zamboni and Uwe Sauer},
  booktitle={Molecular systems biology},
  year={2010}
}
What is the relationship between enzymes and metabolites, the two major constituents of metabolic networks? We propose three alternative relationships between enzyme capacity and metabolite concentration alterations based on a Michaelis-Menten kinetic; that is enzyme capacities, metabolite concentrations, or both could limit the metabolic reaction rates. These relationships imply different correlations between changes in enzyme capacity and metabolite concentration, which we tested by… CONTINUE READING