Traction stress in focal adhesions correlates biphasically with actin retrograde flow speed

@article{Gardel2008TractionSI,
  title={Traction stress in focal adhesions correlates biphasically with actin retrograde flow speed},
  author={Margaret L. Gardel and Benedikt Sabass and Lin Ji and Gaudenz Danuser and Ulrich S. Schwarz and Clare M. Waterman},
  journal={The Journal of Cell Biology},
  year={2008},
  volume={183},
  pages={999 - 1005}
}
How focal adhesions (FAs) convert retrograde filamentous actin (F-actin) flow into traction stress on the extracellular matrix to drive cell migration is unknown. Using combined traction force and fluorescent speckle microscopy, we observed a robust biphasic relationship between F-actin speed and traction force. F-actin speed is inversely related to traction stress near the cell edge where FAs are formed and F-actin motion is rapid. In contrast, larger FAs where the F-actin speed is low are… CONTINUE READING
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