Traction stress analysis and modeling reveal that amoeboid migration in confined spaces is accompanied by expansive forces and requires the structural integrity of the membrane-cortex interactions.

@article{Yip2015TractionSA,
  title={Traction stress analysis and modeling reveal that amoeboid migration in confined spaces is accompanied by expansive forces and requires the structural integrity of the membrane-cortex interactions.},
  author={Ai Kia Yip and Keng-Hwee Chiam and Paul Matsudaira},
  journal={Integrative biology : quantitative biosciences from nano to macro},
  year={2015},
  volume={7 10},
  pages={
          1196-211
        }
}
Leukocytes and tumor cells migrate via rapid shape changes in an amoeboid-like manner, distinct from mesenchymal cells such as fibroblasts. However, the mechanisms of how rapid shape changes are caused and how they lead to migration in the amoeboid mode are still unclear. In this study, we confined differentiated human promyelocytic leukemia cells between opposing surfaces of two pieces of polyacrylamide gels and characterized the mechanics of fibronectin-dependent mesenchymal versus… 

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