Traction force microscopy in Dictyostelium reveals distinct roles for myosin II motor and actin-crosslinking activity in polarized cell movement.

@article{Lombardi2007TractionFM,
  title={Traction force microscopy in Dictyostelium reveals distinct roles for myosin II motor and actin-crosslinking activity in polarized cell movement.},
  author={Maria L Lombardi and David A. Knecht and Micah Dembo and Juliet P. Lee},
  journal={Journal of cell science},
  year={2007},
  volume={120 Pt 9},
  pages={
          1624-34
        }
}
Continuous cell movement requires the coordination of protrusive forces at the leading edge with contractile forces at the rear of the cell. Myosin II is required to generate the necessary contractile force to facilitate retraction; however, Dictyostelium cells that lack myosin II (mhcA-) are still motile. To directly investigate the role of myosin II in contractility we used a gelatin traction force assay to measure the magnitude and dynamic redistribution of traction stresses generated by… CONTINUE READING

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