Traction Dynamics of Filopodia on Compliant Substrates

@article{Chan2008TractionDO,
  title={Traction Dynamics of Filopodia on Compliant Substrates},
  author={Clarence E Chan and David J. Odde},
  journal={Science},
  year={2008},
  volume={322},
  pages={1687 - 1691}
}
Cells sense the environment's mechanical stiffness to control their own shape, migration, and fate. To better understand stiffness sensing, we constructed a stochastic model of the “motor-clutch” force transmission system, where molecular clutches link F-actin to the substrate and mechanically resist myosin-driven F-actin retrograde flow. The model predicts two distinct regimes: (i) “frictional slippage,” with fast retrograde flow and low traction forces on stiff substrates and (ii) oscillatory… 
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643 Citations

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