Tracking the transdermal penetration pathways of optimized curcumin-loaded chitosan nanoparticles via confocal laser scanning microscopy.

@article{AbdelHafez2018TrackingTT,
  title={Tracking the transdermal penetration pathways of optimized curcumin-loaded chitosan nanoparticles via confocal laser scanning microscopy.},
  author={Salma M Abdel-Hafez and Rania M. Hathout and Omaima Ahmed Sammour},
  journal={International journal of biological macromolecules},
  year={2018},
  volume={108},
  pages={
          753-764
        }
}
Curcumin-loaded chitosan nanoparticles intended for transdermal delivery were successfully prepared, optimized and their fate, interaction and pathway through the skin were tracked. D-optimal response surface methodology was used for the nanoparticles optimization. Xy and z-stack confocal laser scanning microscopic images were used for the particles tracking after measuring the drug permeation through the skin using Franz diffusion cells. Very small particle sizes in the range of 33.85-199.23nm… Expand
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