Tracking the establishment of local endemic populations of an emergent enteric pathogen.

  title={Tracking the establishment of local endemic populations of an emergent enteric pathogen.},
  author={Kathryn E Holt and Tran Vu Thieu Nga and Duy Pham Thanh and H. Vinh and Dong Wook Kim and My Phan Vu Tra and James Ian Campbell and Nguyen Van Minh Hoang and Nguyen Thanh Vinh and Pham Van Minh and Cao Thu Thuy and Tran Thu Thi Nga and Corinne Thompson and Tran Thi Ngoc Dung and Nguyen Thi Khanh Nhu and Phat Voong Vinh and Pham Thi Ngoc Tuyet and Hoang Le Phuc and Nguyen Thi Nam Lien and Bui Duc Phu and Nguyen Thi Thuy Ai and Nguyen Manh Tien and Nguyen Dong and Christopher M Parry and Tran Tinh Hien and Jeremy J. Farrar and Julian Parkhill and Gordon Dougan and Nicholas R Thomson and Stephen Baker},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={110 43},
Shigella sonnei is a human-adapted pathogen that is emerging globally as the dominant agent of bacterial dysentery. To investigate local establishment, we sequenced the genomes of 263 Vietnamese S. sonnei isolated over 15 y. Our data show that S. sonnei was introduced into Vietnam in the 1980s and has undergone localized clonal expansion, punctuated by genomic fixation events through periodic selective sweeps. We uncover geographical spread, spatially restricted frontier populations, and… CONTINUE READING
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