Tracking the elusive antiestrogenic effect of melatonin: a new methodological approach.

@article{Girgert2003TrackingTE,
  title={Tracking the elusive antiestrogenic effect of melatonin: a new methodological approach.},
  author={Rainer Girgert and Christian Bartsch and Steven Marc Hill and Rolf Kreienberg and Volker Hanf},
  journal={Neuro endocrinology letters},
  year={2003},
  volume={24 6},
  pages={
          440-4
        }
}
OBJECTIVES Detection of the antiestrogenic effect of melatonin on various breast cancer cell lines and its dependence of the differential expression of estrogen receptors (ERalpha and ERbeta) and melatonin receptors (mt1 and RZRalpha). SETTING AND DESIGN Dose-response curves of estradiol were determined in 6 different breast cancer cell lines using a colorimetric proliferation assay in the absence or presence of various melatonin concentrations. METHODS In order to detect the minor growth… CONTINUE READING

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