Tracking retrograde flow in keratocytes: news from the front.

  title={Tracking retrograde flow in keratocytes: news from the front.},
  author={Pascal Vallotton and Gaudenz Danuser and Sophie Bohnet and Jean-Jacques Meister and Alexander B. Verkhovsky},
  journal={Molecular biology of the cell},
  volume={16 3},
Actin assembly at the leading edge of the cell is believed to drive protrusion, whereas membrane resistance and contractile forces result in retrograde flow of the assembled actin network away from the edge. Thus, cell motion and shape changes are expected to depend on the balance of actin assembly and retrograde flow. This idea, however, has been undermined by the reported absence of flow in one of the most spectacular models of cell locomotion, fish epidermal keratocytes. Here, we use… CONTINUE READING

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