Tracking progesterone receptor-mediated actions in breast cancer.

@article{Knutson2014TrackingPR,
  title={Tracking progesterone receptor-mediated actions in breast cancer.},
  author={Todd P. Knutson and Carol A. Lange},
  journal={Pharmacology & therapeutics},
  year={2014},
  volume={142 1},
  pages={114-25}
}
Ovarian steroid hormones contribute to breast cancer initiation and progression primarily through the actions of their nuclear transcription factors, the estrogen receptor alpha (ERα) and progesterone receptors (PRs). These receptors are important drivers of the luminal A and B subtypes of breast cancer, where estrogen-blocking drugs have been effective endocrine therapies for patients with these tumors. However, many patients do not respond, or become resistant to treatment. When endocrine… CONTINUE READING
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