Tracking mesenchymal stem cell contributions to regeneration in an immunocompetent cartilage regeneration model.

@article{Zwolanek2017TrackingMS,
  title={Tracking mesenchymal stem cell contributions to regeneration in an immunocompetent cartilage regeneration model.},
  author={Daniela Zwolanek and Mar{\'i}a Satu{\'e} and Verena Proell and Jos{\'e} R Godoy and Kathrin I. Od{\"o}rfer and Magdalena Flicker and Sigrid Christa Hoffmann and Thomas R{\"u}licke and Reinhold G Erben},
  journal={JCI insight},
  year={2017},
  volume={2 20}
}
It is currently controversially discussed whether mesenchymal stem cells (MSC) facilitate cartilage regeneration in vivo by a progenitor- or a nonprogenitor-mediated mechanism. Here, we describe a potentially novel unbiased in vivo cell tracking system based on transgenic donor and corresponding immunocompetent marker-tolerant recipient mouse and rat lines in inbred genetic backgrounds. Tolerance of recipients was achieved by transgenic expression of an immunologically neutral but… CONTINUE READING
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