Tracking kinesin-driven movements with nanometre-scale precision

@article{Gelles1988TrackingKM,
  title={Tracking kinesin-driven movements with nanometre-scale precision},
  author={Jeff Gelles and Bruce J. Schnapp and Michael P Sheetz},
  journal={Nature},
  year={1988},
  volume={331},
  pages={450-453}
}
Several enzyme complexes drive cellular movements by coupling free energy-liberating chemical reactions to the production of mechanical work1–3. A key goal in the study of these systems is to characterize at the molecular level mechanical events associated with individual reaction steps in the catalytic cycles of single enzyme molecules. Ideally, one would like to measure movements driven by single (or a few) enzyme molecules with sufficient temporal resolution and spatial precision that these… CONTINUE READING
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